GC-MS analysis and in vitro anti-androgenic activity of Kaempferia rotunda Linn extract
##plugins.themes.bootstrap3.article.sidebar##
Published
Sep 15, 2017
##plugins.themes.bootstrap3.article.main##
Abstract
Testosterone is converted to a more potent androgen, dihydrotestosterone (DHT) by 5α-reductase and causes various hormonal actions. Anti-androgen can be used for the treatment of several disorders related to male sex hormone. In this study, the in vitro anti-androgenic activity and chemical components of hexane, dicholomethane and ethanolic extracts of Kaempferia rotunda Linn. rhizome were investigated. The various concentrations of extracts were tested on anti-androgenic activity by acting against the conversion of testosterone. The hexane extract was the most potent (IC50 = 0.43 ± 0.10 mg/mL) and showed the IC50 value in the same range to that of positive control; ethinylestradiol (IC50 = 0.26 ± 0.02 mg/mL). The different chemical profiles of all extracts studied were observed by GC-MS. The results indicated that most of volatile components including mono- and sesquiterpenes were present in hexane extract. Further studies on isolation and identification of active components are needed. This plant might be a new source for anti-androgens.
References
Areerak, W. (2011). Effects of a Fall Preventive Beha Vior Promotion Program on Perceived Self-Efficacy, Outcome Expectation in Performance and Fall Preventine Behavior Among Community-Dwelling Older Adults at Risk of Falling. (Master’s Thesis). Burapha University, Chonburi.
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). Of Falls Among The Elderly in Thailand. Retrieved from http://www.thaincd.2557.com/document/file/violence/Fact%20sheet%20-%20Falls%20in%20Elderly.pdf
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). The number and rate of deaths from falls (W00 - W19) in people aged 60 years and over a hundred thousand people per year from 2008 - 2013 by the Office of Disease Prevention and Control 1 - 12 in Bangkok. Retrieved from http://www.thaincd.com/document/
file/violence/W00-W19-1-12-51-56.pdf.
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). The Number and Rate of Deaths From Falls (W00 – W19) In People Aged 60 Years and Over a Hundred Thousand People Per Year From 2008-2013, Classified by Province. Retrieved from http://www.thaincd.com/document/file/violence/W00%20-%20W19 Province 2008-2013.pdf.
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). 8 How to Protect “An Old Man” fall After Finding High Mortality Ratio of 1.6 Per Thousand. Retrieved from http://www.thaincd.com/good-stories-view.php?Id= 8695
Daniel, W. W. (1995). Biostatistics: A foundation for analysis in the health sciences. New York: Wiley & Sons.
Green, L., & Krueter, M. (1999). Health Promotion Planning An Education Approach (3rd ed.). Toronto: Mayfield Publishing Company.
Health Education Division, Department of Health Service Support. (2017). Guideline for changing of health behavior in province level. Retrieved from file:///D:/PI_RY/09186537/Downloads/140920151231113793_linkhed.pdf
Ketpetch, P. (2010). An Application of Health Belief Model and Social Support for Falling Prevention Among Elderly in Chaoprayayomraj Hospital, Suphan Buri Province. (Master’s Thesis). Mahasarakarm University, Mahasarakarm.
Khuankwai, K. (2007). Factors Related to Falls Among Community-Dwelling Eldrely Peoply. (Master’s thesis). Khon Kaen University, Khon Kaen.
Kitkumhang, V. (2005). Risk Factors Associated With Falling of Elderly People in Community. (Master’s thesis). Naresuan University, Phitsanulok.
Kumsri, W. (2006). Health Beliefs Influencing Fall-Preventive Behaviors in the Elderly with Hypertension. (Master’s thesis). Prince of Singkla University, Songkla.
Malahom, R. (2011). The Effect of Health Belief Theory with Social Support on Fall Prevention among the Elderly in Pho Sai District. (Master’s Thesis). Mahasarkarm University, Mahasarkarm.
National Statistical office Ministry of Information and Communication Technology. (2014). Bangkok, Thailand: Text and journal publication.
Oumlarmai, S. (2010). A Study of Relationships between Personal factors Perceived Benefits Barriersand Self-efficacy in Fall Prevention and Fall Preventive Behaviors among the Elderly living in a Community. (Master’s thesis). Khon Kaen University, Khon Kaen.
Pimdee, A. (2010). Effectiveness of Health Education Progrem by Application Health Belief Model and Social Support with Paslop Dancing Exercise for Falling Prevention in Pre-Elderly Thai Female, Roi-Et Province. (Master’s Thesis). Khon Kaen University, Khon Kaen.
Research Institute and Development seniors Thailand. Report seniors Thailand 2014.Retrieved from http://thaitgri.org
Research Institute and Development seniors Thailand. Report seniors Thailand 2015. Retrieved from http://thaitgri.org
Statistical register system. (2012). The number of populations classifiled by age in Chonburi provirce. Retrieved from http://stat.dopa.go.th/stat/statnew/
upstat_age_disp.php
Sukhothai Thammathirat open University. (2017). The effect of Thailand in to The elderly society. Retrieved from http://www.stou.ac.th/stouonline/lom/data/sec/ Lom12/05-04.html
Thiya, N. (2008). Fall Prevention Related Behavior Among Elder Patients Seeking Treatment at Female Trauma Ward of Prarnongkutklao Hopital. (Master’s thesis). Kasetsart University, Bangkokbank.
Wongpanitkul, K. (2012). Factors Related to Fear of Falling Among Community-Dwelling Older Adults in Kanchanaburi Province. (Master’s thesis). Burapha University, Chonburi.
Wontasong, N. (2008). Factors Related to Fall in the Fall-Risked Elderly Living in a Community. (Master’s Thesis). Khon Kaen University, Khon Kaen.
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). Of Falls Among The Elderly in Thailand. Retrieved from http://www.thaincd.2557.com/document/file/violence/Fact%20sheet%20-%20Falls%20in%20Elderly.pdf
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). The number and rate of deaths from falls (W00 - W19) in people aged 60 years and over a hundred thousand people per year from 2008 - 2013 by the Office of Disease Prevention and Control 1 - 12 in Bangkok. Retrieved from http://www.thaincd.com/document/
file/violence/W00-W19-1-12-51-56.pdf.
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). The Number and Rate of Deaths From Falls (W00 – W19) In People Aged 60 Years and Over a Hundred Thousand People Per Year From 2008-2013, Classified by Province. Retrieved from http://www.thaincd.com/document/file/violence/W00%20-%20W19 Province 2008-2013.pdf.
Bureau of Non-Communicable Diseases Department of Disease Control, Ministry of Health. (2014). 8 How to Protect “An Old Man” fall After Finding High Mortality Ratio of 1.6 Per Thousand. Retrieved from http://www.thaincd.com/good-stories-view.php?Id= 8695
Daniel, W. W. (1995). Biostatistics: A foundation for analysis in the health sciences. New York: Wiley & Sons.
Green, L., & Krueter, M. (1999). Health Promotion Planning An Education Approach (3rd ed.). Toronto: Mayfield Publishing Company.
Health Education Division, Department of Health Service Support. (2017). Guideline for changing of health behavior in province level. Retrieved from file:///D:/PI_RY/09186537/Downloads/140920151231113793_linkhed.pdf
Ketpetch, P. (2010). An Application of Health Belief Model and Social Support for Falling Prevention Among Elderly in Chaoprayayomraj Hospital, Suphan Buri Province. (Master’s Thesis). Mahasarakarm University, Mahasarakarm.
Khuankwai, K. (2007). Factors Related to Falls Among Community-Dwelling Eldrely Peoply. (Master’s thesis). Khon Kaen University, Khon Kaen.
Kitkumhang, V. (2005). Risk Factors Associated With Falling of Elderly People in Community. (Master’s thesis). Naresuan University, Phitsanulok.
Kumsri, W. (2006). Health Beliefs Influencing Fall-Preventive Behaviors in the Elderly with Hypertension. (Master’s thesis). Prince of Singkla University, Songkla.
Malahom, R. (2011). The Effect of Health Belief Theory with Social Support on Fall Prevention among the Elderly in Pho Sai District. (Master’s Thesis). Mahasarkarm University, Mahasarkarm.
National Statistical office Ministry of Information and Communication Technology. (2014). Bangkok, Thailand: Text and journal publication.
Oumlarmai, S. (2010). A Study of Relationships between Personal factors Perceived Benefits Barriersand Self-efficacy in Fall Prevention and Fall Preventive Behaviors among the Elderly living in a Community. (Master’s thesis). Khon Kaen University, Khon Kaen.
Pimdee, A. (2010). Effectiveness of Health Education Progrem by Application Health Belief Model and Social Support with Paslop Dancing Exercise for Falling Prevention in Pre-Elderly Thai Female, Roi-Et Province. (Master’s Thesis). Khon Kaen University, Khon Kaen.
Research Institute and Development seniors Thailand. Report seniors Thailand 2014.Retrieved from http://thaitgri.org
Research Institute and Development seniors Thailand. Report seniors Thailand 2015. Retrieved from http://thaitgri.org
Statistical register system. (2012). The number of populations classifiled by age in Chonburi provirce. Retrieved from http://stat.dopa.go.th/stat/statnew/
upstat_age_disp.php
Sukhothai Thammathirat open University. (2017). The effect of Thailand in to The elderly society. Retrieved from http://www.stou.ac.th/stouonline/lom/data/sec/ Lom12/05-04.html
Thiya, N. (2008). Fall Prevention Related Behavior Among Elder Patients Seeking Treatment at Female Trauma Ward of Prarnongkutklao Hopital. (Master’s thesis). Kasetsart University, Bangkokbank.
Wongpanitkul, K. (2012). Factors Related to Fear of Falling Among Community-Dwelling Older Adults in Kanchanaburi Province. (Master’s thesis). Burapha University, Chonburi.
Wontasong, N. (2008). Factors Related to Fall in the Fall-Risked Elderly Living in a Community. (Master’s Thesis). Khon Kaen University, Khon Kaen.
Keywords
Kaempferia rotunda; Anti-androgen; 5α-Reductase; GC-MS; Sesquiterpenes
Section
Research Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
##plugins.themes.bootstrap3.article.details##
How to Cite
SUPHROM, Nungruthai et al.
GC-MS analysis and in vitro anti-androgenic activity of Kaempferia rotunda Linn extract.
Naresuan University Journal: Science and Technology (NUJST), [S.l.], v. 25, n. 4, p. 34-43, sep. 2017.
ISSN 2539-553X.
Available at: <https://www.journal.nu.ac.th/NUJST/article/view/1482>. Date accessed: 09 feb. 2023.