A triterpenoid and Steroids from the Twigs of Millettia utilis Dunn. and Their Antioxidant Activities
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Published
Feb 12, 2020
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Abstract
A triterpenoid, betulin together with two steroids, b-sitostenone and pregnenolone were isolated from dichloromethane crude extract in the twigs of Millettia utilis Dunn. The structures of all isolated compounds were elucidated by basic NMR spectroscopy and compared with previous literature. All compounds were tested for their antioxidant activities. Betulin revealed moderate activity against ABTS assay.
Keywords: Millettia utilis Dunn., steroids, triterpenoid, ABTS, antioxidant activities
References
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Tijjani, A., Ndukwe, I. G., & Ayo, R. G. (2012). Isolation and Characterization of Lup-20(29)-ene-3, 28-diol (Betulin) from the Stem-Bark of Adenium obesum (Apocynaceae). Tropical Journal of Pharmaceutical Research, 11(2), 259-262.
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Ara, K., Rahman, M. S., Rahman, A. H. M. M., Hasan, C. M., & Rashid, M. A. (2009). Terpenoids and Coumarin from Bursera serrata Wall. Dhaka University Journal of Pharmaceutical Sciences, 8(2), 107-110.
Arnao, M. B., Cano, A., & Acosta, M. (2001). The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chemistry, 73, 239–244.
Chen, J. J., Duh, C. Y., & Chen, I. S. (2005). Cytotoxic Chromenes from Myriactis humilis. Planta Medica, 71(4), 370-372.
Derese, S., Barasa, L., Akala, H. M., Yusut, A. O., Kamau, E., Heydenreich, M., & Yenesew, A. (2014). 4-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species. Phytochemistry Letters, 8, 69-72.
Gauthier, C., Legault, J., Lavoie, S., Rondeau, S., Tremblay, S., & Pichette, A. (2009). Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins. Journal of Natural Products, 72, 72-81.
Huo, X., Zhang, L., Gao, L., Guo, Y., Zhang, L., Li, L., … Cao, L. (2015). Antiinflammatory and Analgesic Activities of Ethanol Extract and Isolated Compounds from Millettia pulchra. Biological and Pharmaceutical Bulletin, 38, 1328–1336.
Kim, D. O., Lee, K. W., Lee, H. J., & Lee, C. Y. (2002). Vitamin C Equivalent Antioxidant Capacity (VCEAC) of Phenolic Phytochemicals. Journal of Agricultural and Food Chemistry. 50, 3713-3717.
Ngandeu, F., Bezabih, M., Ngamga, D., Tchinda, A. T., Ngadjui, B. T., Abegaz, B. M., … Tillequin, F. (2008). Rotenoid derivatives and other constituents of the twigs of Millettia duchesnei. Phytochemistry, 69, 258-263.
Pancharoen, O, Athipornchai, A., Panthong, A., & Taylor, W. C. (2008). Isoflavones and Rotenoids from the Leaves of Millettia brandisiana. Chemiical andPha rmaceutical Bulletin, 56, 835–838.
Phrutivorapongkul, A., Lipipan, V., Ruangrungsi, N., Kirtikar, K., Nishikawa, K., Maruyama, S., … Ishikawa, T. (2003). Studies on the Chemical Constituents of Stem Bark of Millettia leucantha : Isolation of New Chalcones with Cytotoxic, Anti-herpes Simplex Virus and Anti-inflammatory Activities. Chemiical andPha rmaceutical Bulletin, 51, 187–190.
Prachasittikul, S., Supapong, S., Worachartcheewan, A., Lawung, R., Ruchirawat, S., & Prachasittikul, V. (2009). Bioactive Metabolites from Spilanthes acmella Murr. Molecules, 14, 850-867.
Sheu, J. H., Chang, K. C., & Duh, C. Y. (2000). A Cytotoxic 5,8-Epidioxysterol from a Soft Coral Sinularia Species. Journal of Natural Products, 63, 149-151.
Sritularak, B., & Likhitwitayawuid, K. (2006). Flavonnoids from the pods of Millettia erythrocalyx. Phytochemistry, 67, 812-817.
Sritularak, B., Likhitwitayawuid, K., Conrad, J., & Kraus, W. (2002). Flavonnoids from the roots of Millettia erythrocalyx. Phytochemistry, 61, 943-947.
Tijjani, A., Ndukwe, I. G., & Ayo, R. G. (2012). Isolation and Characterization of Lup-20(29)-ene-3, 28-diol (Betulin) from the Stem-Bark of Adenium obesum (Apocynaceae). Tropical Journal of Pharmaceutical Research, 11(2), 259-262.
Wang, F. (2014). 1H-NMR spectra of common steroids, triterpenoids. Retrieved from http://www.wangfei.
ac.cn/article/nmrspectra/7/1/39.
Zahari, N. H., & Said, I. M. (2013). Steroidal Compounds from the Roots of Holarrhena currtisii. The Malaysian Journal of Analytical Sciences, 17(2), 281-285.
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Research Articles
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How to Cite
RUKSILP, Thanatip.
A triterpenoid and Steroids from the Twigs of Millettia utilis Dunn. and Their Antioxidant Activities.
Naresuan University Journal: Science and Technology (NUJST), [S.l.], v. 28, n. 1, p. 49-54, feb. 2020.
ISSN 2539-553X.
Available at: <https://www.journal.nu.ac.th/NUJST/article/view/Vol-8-No-1-2020-49-54>. Date accessed: 25 apr. 2024.
doi: https://doi.org/10.14456/nujst.2020.5.