An Efficient Synthesis of Imidazo[1,2-a]pyridines


Piyawat Paengphua Uthai Wichai Sirirat Chancharunee


     Imidazo[1,2-a]pyridines are useful building blocks for a number of biologically and pharmaceutically valuable compounds. Its synthetic method started from the reaction of 2-aminopyridines with acetophenones. However, the existing synthetic methods have drawbacks such as relatively high reaction temperatures, long reaction times and the difficult post-treatment. In this article, an improved synthetic method with high yield and simple steps for the synthesis of imidazo[1,2-a]pyridines was reported. It is an improved method that CsF-Celite was used in post-treatment, which enhanced the total yield, and the operations were effectually simplified by the one-pot method. Moreover, CsF-Celite can be recovered for subsequent reactions and reused without any loss of efficiency.

Keywords: Celite, Cesium Fluoride, One-pot synthesis


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Research Articles


How to Cite
PAENGPHUA, Piyawat; WICHAI, Uthai; CHANCHARUNEE, Sirirat. An Efficient Synthesis of Imidazo[1,2-a]pyridines. Naresuan University Journal: Science and Technology (NUJST), [S.l.], v. 27, n. 3, p. 43-54, july 2019. ISSN 2539-553X. Available at: <>. Date accessed: 21 oct. 2019. doi: